Since two-child policy open, including women, maternal team growing, each family to pursue high quality bearing more and more strong, good any pregnancy a hospital to carry out the inspection checks, such as down syndrome screening, colour to exceed malformation screening, screening for gestational diabetes (OGTT experiment), the TORCH screening, hereditary deafness gene detection, late pregnancy weekly cardiac monitoring, etc., after finish check in pregnant women are often asked the doctor, "there will be no should check project?"

.

In fact, pregnant and pregnant women should also be tested for vitamins.

 

Status and significance

When it comes to vitamins, you may have on its importance is not enough, but vitamin do close connection and our health, a simple experience allows us to stress the significance of vitamin testing: was born two months baby, asthma symptoms, many people would first think of whether because of infection bronchitis, pneumonia and so on, using a variety of drugs, still no improvement, the result was caused by calcium deficiency, it is well known calcium deficiency is due to a lack of vitamin D, vitamin inspection is of great significance.

Vitamins are an important element of life in the human body.

There are many kinds of vitamins, including vitamin B1 (thiamine), vitamin B2 (riboflavin), vitamin B3 (niacin), vitamin B12, vitamin A, vitamin D, vitamin E, vitamin K and so on.

This paper takes vitamin D as an example to illustrate the significance of vitamin testing in pregnant and newborn women.

Vitamin D deficiency is best known for causing orthopedic diseases such as rickets, but the risks of vitamin D deficiency in pregnant women are also significant.

Due to the lack of outdoor activities and less exposure to sunlight, as well as the need for fetal growth and development in pregnancy and the impact of factors such as twins, many pregnant women during pregnancy will appear vitamin D deficiency.

Vitamin D is involved in several metabolic pathways in the body, such as calcium-phosphorus metabolism.

Vitamin D deficiency can lead to serious consequences, especially for women during pregnancy can cause: neonatal delayed low blood calcium, increase the offspring early Ⅰ diabetes, infantile allergic diseases, infants with respiratory syncytial virus infection, to a certain extent, increase the risk of a language barrier in childhood, etc., have the latest research shows that vitamin D deficiency can lead to heart disease, diabetes, autoimmune disease, several types of tumors.

Studies have also shown that vitamin D concentrations <37.5nmol/L (15ng/ml) in the first trimester increase a woman's risk of developing pregnancy-induced hypertension by a factor of five.

25 (OH) D is the main storage form of vitamin D in the body, accounting for more than 95% of the total amount. Because of its long half-life (2-3 weeks), and is not affected by blood calcium and parathyroid hormone hormones, it is recognized as the best indicator for objective evaluation of vitamin nutritional status.

 

In clinical work should focus on the following topics: vitamin D deficiency is common in patients with gestational diabetes mellitus and and vitamin D deficiency is one of the important causes of insulin resistance, timely detection of 25 (OH) 2 D3 concentrations, take corresponding measures, have certain significance for prevention and treatment of gestational diabetes, clinical can be regulated by vitamin D levels in the pathogenesis of gestational diabetes or blood sugar levels to intervene.

Numerous animal and human studies have shown the role of vitamin D in the immune system, lung development, and anti-inflammatory effects.

In children with asthma, vitamin D supplementation can increase the immunomodulatory effect of dexamethasone on asthma.

Prenatal vitamin D is associated with adverse pregnancy outcomes such as cesarean section, stillbirth, vaginal infection, periodontitis, and dysplasia of the nervous system.

Therefore, the inclusion of vitamin D in prenatal screening programs is a critical work.

 

"Vitamin D deficiency rickets prevention and treatment recommendations" point out: if the condition of pregnant women, pregnancy 3 months should be tested for blood vitamin D concentration.

If vitamin D deficiency occurs, vitamin D supplements may be appropriate to improve and maintain normal levels.

Clinical practice guidelines for the assessment, treatment, and prevention of vitamin D deficiency published by the American society for endocrinology in 2011 suggested that people with serum levels of 25-hydroxyvitamin D < 20ng/ml in peripheral blood should be diagnosed as vitamin D deficient.

Vitamin D is so important to the body that testing during pregnancy is crucial.

 

Technical means

Based on the significance of vitamin D testing, it is clear that multivitamin testing is of great significance in pregnant and newborn women.

Due to the poor stability of some vitamins, how to accurately detect vitamin levels, it is particularly important, which has become the focus of discussion of vitamin testing topic.

One of the major problems in clinical testing and practice is accuracy and precision, as well as good sensitivity to correctly identify patients with high levels of vitamin D deficiency.

At present, the main detection methods in clinical testing are: liquid chromatography tandem mass spectrometry (lc-ms /MS), roche electrochemical luminescence immunoassay.

The joint committee on the traceability of laboratory medicine considers lc-ms/MS as the "gold standard" for vitamin D testing. Mass spectrometry USES dehydrated ions as the parent ions, and has high reproducibility and accuracy.

Vitamin deficiency will seriously affect maternal and infant health.

Therefore, in order to ensure maternal and child health, vitamin screening is very critical, early detection, early treatment.

As inspectors, should continue to learn, to ensure the accuracy of the results of vitamin testing, with the clinician, pregnant and pregnant women and infants vitamin testing work well.