Individualized medication solutions

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Therapeutic drug monitoring (TDM) is to determine the drug exposure, pharmacological markers or efficacy indicators in patients, use quantitative pharmacological model, take the drug treatment window as the benchmark, and develop the individualized drug delivery scheme suitable for patients. The core is individualized drug therapy


TDM development milestone

Clinical significance of TDM


TDM sampling time: steady state concentration

  • Most of the effective concentration range of drugs is determined when the concentration of drugs in the plasma reaches or approaches the steady-state concentration (CSS). Generally, it takes 4-5 half lives to reach CSS.

  • If the treatment effect is suspected to be unsuccessful, steady-state Valley concentration is taken as an important index.

  • If toxic reactions due to excessive drug concentration are suspected, samples should be taken at peak concentration.

  • Blood should be taken at the end of the interval of administration, i.e. before the next administration.

  • Two blood samples, peak concentration and valley concentration, are often taken for the drugs with fast elimination because of the great fluctuation of blood concentration during the interval of administration.

  • For more than 90% of psychoactive drugs, the steady state can be achieved after one week of continuous administration