[Significance of detection]
Neonatal congenital adrenal hyperplasia (CAH) is a group of diseases caused by the decrease of cortisol synthesized in the fascicular zone of renal cortex. Cortisol is an essential steroid hormone to maintain the normal level of blood glucose, especially to maintain body fluids and electrolytes. Congenital defects in enzymes required for the transformation of precursor compounds into cortisol lead to a variety of CAH types. When one of the enzymes is deficient, it will lead to hyperfunction and adrenal hyperplasia, so it is called congenital adrenal hyperplasia.
21- hydroxylase deficiency (21-OHD) is the most common type of CAH, accounting for over 90%, and its incidence rate is about 1/4500 of newborn, about 75% of which are salt losing. 21 OHD resulted in an increase in 17 hydroxyprogesterone levels. Different mutations of 21 hydroxylase gene lead to different severity of CAH.
CAH can not be cured, but if it can be diagnosed in the early stage, it can be effectively treated by steroid substitutes in time. Due to the large number of individual variations in cortisol secretion, it is also important to monitor the treatment carefully. This means calculating an appropriate replacement amount, that is, the amount of 17 hydroxyprogesterone in serum or whole blood.
17 α - hydroxyprogesterone test kit (fluorescence method) is a quantitative method for the determination of 17 α - hydroxyprogesterone (17 OHP) on the filter paper in vitro.
1. The operation process is detailed in the instruction;
2. Pass the verification of CCD;
3. The product background noise is very low;
4. High sensitivity and specificity;
5. It can be equipped with semi-automatic and full-automatic instruments;